| Primary Identifier | MGI:4457120 | Allele Type | Transgenic |
| Gene | Tg(Alb1-Ren)3Unc | Inheritance Mode | Dominant |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The transgene, inserted into the apolipoprotein locus between the Apoa1 and Apoc3 genes, comprises a single copy of a construct consisting of the liver specific albumin promoter/enhancer, a synthetic cDNA encoding a secreted, hybrid renin protein with a C-terminal Myc epitope tag, and, immediately downstream of the translation termination codon, a 75 bp synthetic AU rich element (ARE) including the domain I sequence of the RNA destabilizing element of the Fos gene, which reduces the half-life of the mRNA. |
