Primary Identifier | MGI:4457607 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Lmna |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Introns 10 and 11 of Lmna were deleted thereby abolishing production of lamin C and producing a only non-farnesylated prelamin A. A point mutation was introduced into exon 12 that changes the cysteine of prelamin A's CaaX motif to a serine (i.e. CSIM to SSIM). |