| First Author | Quante M | Year | 2011 |
| Journal | Cancer Cell | Volume | 19 |
| Issue | 2 | Pages | 257-72 |
| PubMed ID | 21316604 | Mgi Jnum | J:169447 |
| Mgi Id | MGI:4941062 | Doi | 10.1016/j.ccr.2011.01.020 |
| Citation | Quante M, et al. (2011) Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19(2):257-72 |
| abstractText | Carcinoma-associated fibroblasts (CAFs) that express alpha-smooth muscle actin (alphaSMA) contribute to cancer progression, but their precise origin and role are unclear. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone marrow (BM) and derive from mesenchymal stem cells (MSCs). alphaSMA+ myofibroblasts (MFs) are niche cells normally present in BM and increase markedly during cancer progression. MSC-derived CAFs that are recruited to the dysplastic stomach express IL-6, Wnt5alpha and BMP4, show DNA hypomethylation, and promote tumor growth. Moreover, CAFs are generated from MSCs and are recruited to the tumor in a TGF-beta- and SDF-1alpha-dependent manner. Therefore, carcinogenesis involves expansion and relocation of BM-niche cells to the tumor to create a niche to sustain cancer progression. |
