| Primary Identifier | MGI:4458424 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Tecta |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 14 was replaced with a modified one in which nucleotide substitution (T to G) resulted in the amino acid substitution of cysteine with glycine at position 1509 (p.C1509G). This mutation was identified in human patients with autosomal dominant hearing loss. A second silent nucleotide substitution (C to A) at codon for amino acid 1510 was generated to assist in genotypying. An FRT site flanked neomycin resistance gene cassette was inserted into intron 13 and was removed through subsequent flp-mediated recombination. |
