| First Author | Chien CL | Year | 2013 |
| Journal | Exp Neurol | Volume | 248 |
| Pages | 10-5 | PubMed ID | 23726959 |
| Mgi Jnum | J:203633 | Mgi Id | MGI:5528412 |
| Doi | 10.1016/j.expneurol.2013.05.015 | Citation | Chien CL, et al. (2013) Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice. Exp Neurol 248:10-5 |
| abstractText | Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate herein that AC6 existed in tyrosine hydroxylase-positive rostral ventrolateral medulla neurons in the brainstem. Adenylyl cyclase (AC) assays showed lower basal and pituitary adenylate cyclase-activating peptide-evoked AC activities in the brainstem of AC6-null mice, indicating that AC6 is a prominent AC isozyme in the brainstem. Furthermore, two independent lines of AC6-null mice exhibited a much higher SND, recorded from splanchnic sympathetic nerves of neonatal brainstem-spinal cord preparations, than wildtype mice. An assay of urine noradrenaline confirmed this observation. Collectively, AC6 plays a critical role in the regulation of sympathetic tone. |
