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Allele : Tg(Bglap-TGFB2*C226S*C228S)D4Rdk transgene insertion D4, Rik Derynck
Primary Identifier  MGI:4819544 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Bglap-TGFB2*C226S*C228S)D4Rdk
Strain of Origin  (C57BL/6 x DBA/2)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  A 1.8 kb rat osteocalcin promoter fragment was used to direct expression of a human TGF-beta2 cDNA in osteoblasts. The TGF-beta2 cDNA was modified by two point mutations which changed the cysteines normally found at codons 226 and 228 to serines. Eight founders were produced but only founder lines D4 and D5 where characterized. Homozygotes could not be derived from the D4 founder.
  • mutations:
  • Insertion
  • synonyms:
  • D4,
  • D4
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele




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