| Primary Identifier | MGI:4819592 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(NPHS2-icre/ERT2)1Dnsh |
| Inheritance Mode | Not Specified | Strain of Origin | C57BL/6 |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | The coding sequences of (improved) icre and a tamoxifen-inducible estrogen receptor, ERT2, were fused in-frame and put under the control of 2.5 kb NPHS2 (human podocin) promoter region. The icre/ERT2 fragment was followed by the bovine growth hormone polyA (bGHpA) sequence. The linearized construct was microinjected into the pronuclei of fertilized C57BL/6 eggs. Three of four founders successfully transmitted the transgene to their offspring. |
