| First Author | Harp JA | Year | 1984 |
| Journal | J Immunol | Volume | 133 |
| Issue | 1 | Pages | 10-5 |
| PubMed ID | 6233370 | Mgi Jnum | J:7453 |
| Mgi Id | MGI:55923 | Doi | 10.4049/jimmunol.133.1.10 |
| Citation | Harp JA, et al. (1984) Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera. J Immunol 133(1):10-5 |
| abstractText | The effects of Ly-5 alloantisera on the generation of cytotoxic T cells (CTL), on the effector phase of CTL killing, and on polyclonal mitogenesis were studied. Ly-5 antisera added at the beginning of mixed lymphocyte culture (MLC) suppressed the production of CTL in an allele-specific manner. Neither Ly-5.1 nor Ly-5.2 antisera inhibited the generation of cytotoxic effectors by Ly-5.1/Ly-5.2 heterozygous spleen cells; however, a combination of Ly-5.1 and Ly-5.2 antisera markedly suppressed the appearance of Ly-5 heterozygous CTL. Similarly, Ly-5 antisera inhibited the effector phase of CTL killing in an allele-specific manner. In addition, Ly-5 alloantisera specifically blocked concanavalin A and oxidative mitogenesis of splenocytes carrying the appropriate Ly-5 alloantigen. The results are discussed in light of a possible functional role of Ly-5 molecules in immune processes. |
