| First Author | Freeman ML | Year | 2011 |
| Journal | J Immunol | Volume | 187 |
| Issue | 12 | Pages | 6180-4 |
| PubMed ID | 22079983 | Mgi Jnum | J:180405 |
| Mgi Id | MGI:5306208 | Doi | 10.4049/jimmunol.1102745 |
| Citation | Freeman ML, et al. (2011) Cutting edge: activation of virus-specific CD4 T cells throughout gamma-herpesvirus latency. J Immunol 187(12):6180-4 |
| abstractText | CD4 T cells are essential for immune control of gamma-herpesvirus latency. We previously identified a murine MHC class II-restricted epitope in gamma-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that elicits CD4 T cells that are maintained throughout long-term infection. However, it is unknown whether naive cells can be recruited into the antiviral CD4 T cell pool during latency. In this study, we generate a mouse transgenic for a gp150-specific TCR and show epitope-specific activation of transgenic CD4 T cells during acute and latent infections. Furthermore, although only dendritic cells can stimulate virus-specific CD8 T cells during latency, we show that both dendritic cells and B cells stimulate transgenic CD4 T cells. These studies demonstrate that naive CD4 T cells specific for a viral glycoprotein can be stimulated throughout infection, even during quiescent latency, suggesting that CD4 T cell memory is maintained in part by the continual recruitment of naive cells. |
