| First Author | Patrick DM | Year | 2010 |
| Journal | Genes Dev | Volume | 24 |
| Issue | 15 | Pages | 1614-9 |
| PubMed ID | 20679397 | Mgi Jnum | J:163251 |
| Mgi Id | MGI:4821499 | Doi | 10.1101/gad.1942810 |
| Citation | Patrick DM, et al. (2010) Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev 24(15):1614-9 |
| abstractText | Erythrocyte formation occurs throughout life in response to cytokine signaling. We show that microRNA-451 (miR-451) regulates erythropoiesis in vivo. Mice lacking miR-451 display a reduction in hematrocrit, an erythroid differentiation defect, and ineffective erythropoiesis in response to oxidative stress. 14-3-3zeta, an intracellular regulator of cytokine signaling that is repressed by miR-451, is up-regulated in miR-451(-/-) erythroblasts, and inhibition of 14-3-3zeta rescues their differentiation defect. These findings reveal an essential role of 14-3-3zeta as a mediator of the proerythroid differentiation actions of miR-451, and highlight the therapeutic potential of miR-451 inhibitors. |
