| First Author | Tsurusaki S | Year | 2016 |
| Journal | Int Immunol | Volume | 28 |
| Issue | 12 | Pages | 605-609 |
| PubMed ID | 27932517 | Mgi Jnum | J:247192 |
| Mgi Id | MGI:5922151 | Doi | 10.1093/intimm/dxw046 |
| Citation | Tsurusaki S, et al. (2016) Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Int Immunol 28(12):605-609 |
| abstractText | TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G+ neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas-TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis. |
