| First Author | Lin YH | Year | 2020 |
| Journal | Int Immunol | Volume | 32 |
| Issue | 3 | Pages | 213-219 |
| PubMed ID | 31793637 | Mgi Jnum | J:286569 |
| Mgi Id | MGI:6394226 | Doi | 10.1093/intimm/dxz075 |
| Citation | Lin YH, et al. (2020) Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice. Int Immunol 32(3):213-219 |
| abstractText | Mast cells (MCs) play a critical role in oral allergen-induced anaphylaxis. However, the contribution of basophils to the anaphylaxis remains unclear. The inhibitory immunoreceptor Allergin-1 is highly expressed on MCs and basophils and inhibits FcepsilonRI-mediated signaling in MCs. Here, we show that Allergin-1-deficient (Milr1-/-) mice developed more severe hypothermia, a higher mortality rate and a greater incidence of diarrhea than did wild-type (WT) mice in an oral ovalbumin (OVA)-induced food allergy model. MC-deficient Mas-TRECK mice, which had been reconstituted with either WT or Milr1-/- bone marrow-derived cultured MCs, did not develop hypothermia in this food allergy model. On the other hand, depletion of basophils by injection of anti-CD200R3 antibody rescued Milr1-/- mice from lethal hypothermia but not from diarrhea. In vitro analyses demonstrated that Allergin-1 inhibits IgE-dependent activation of both human and mouse basophils. Thus, Allergin-1 on basophils selectively suppresses oral allergen-induced anaphylaxis. |
