Primary Identifier | MGI:4821735 | Allele Type | Transgenic |
Attribute String | Inducible, Recombinase | Gene | Tg(Dbh-cre/ERT2)198.1Hroh |
Strain of Origin | C57BL/6 | Induced With | tamoxifen |
Is Recombinase | true | Is Wild Type | false |
molecularNote | A cre-ERT2 cassette with a polyA sequence was inserted into a BAC containing the mouse Dbh gene by homologous recombination, resulting in cre expression directed by the Dbh promoter. This construct was integrated into the C57BL/6 background. Cre induction by tamoxifen in mice crossed to a reporter line exhibited cre activity in noradrenergic cells (sympathetic ganglia, adrenal chromaffin cells, and the locus ceruleus). |