| Primary Identifier | MGI:4839643 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Prnp-TARDBP*A315T)23Jlel |
| Strain of Origin | (C57BL/6 x SJL)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The mouse promoter drives neuronal expression of the human cDNA with point mutations that result in the amino acid substitution of threonine for alanine at position 315 (A315T). This mutation was identified in human patients with amyotrophic lateral sclerosis with TARDBP proteinopathies. Four lines were established (23, 27, 35, and 61). |
