| Primary Identifier | MGI:4839478 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Krt19-KRAS*G12V)AAru |
| Strain of Origin | C57BL/6 x SJL | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A 2.1-kb genomic fragment of the 5'-flanking region/promoter of the mouse Keratin 19 gene drives expression of the full-length human K-ras gene with a point mutation in codon 12 that alters a Gly residue to a Val in the encoded protein. An intronic fragment from the rabbit beta-globin gene was inserted between the promoter and mutated KRAS gene to enhance gene expression. In addition to line A, lines B and C were also created. |
