| First Author | Tchou G | Year | 2023 |
| Journal | JACC Basic Transl Sci | Volume | 8 |
| Issue | 10 | Pages | 1357-1378 |
| PubMed ID | 38094680 | Mgi Jnum | J:358633 |
| Mgi Id | MGI:7782693 | Doi | 10.1016/j.jacbts.2023.05.009 |
| Citation | Tchou G, et al. (2023) Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling. JACC Basic Transl Sci 8(10):1357-1378 |
| abstractText | A specific genetic variant associated with atrial fibrillation risk, rs17171731, was identified as a regulatory variant responsible for controlling FAM13B expression. The atrial fibrillation risk allele decreases FAM13B expression, whose knockdown alters the expression of many genes in stem cell-derived cardiomyocytes, including SCN2B, and led to pro-arrhythmogenic changes in the late sodium current and Ca(2+) cycling. Fam13b knockout mice had increased P-wave and QT interval duration and were more susceptible to pacing-induced arrhythmias vs control mice. FAM13B expression, its regulation, and downstream effects are potential targets for investigation of patient-specific therapeutics. |
