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Publication : Cone contacts, mosaics, and territories of bipolar cells in the mouse retina.

First Author  Wässle H Year  2009
Journal  J Neurosci Volume  29
Issue  1 Pages  106-17
PubMed ID  19129389 Mgi Jnum  J:144342
Mgi Id  MGI:3830766 Doi  10.1523/JNEUROSCI.4442-08.2009
Citation  Wassle H, et al. (2009) Cone contacts, mosaics, and territories of bipolar cells in the mouse retina. J Neurosci 29(1):106-17
abstractText  We report a quantitative analysis of the different bipolar cell types of the mouse retina. They were identified in wild-type mice by specific antibodies or in transgenic mouse lines by specific expression of green fluorescent protein or Clomeleon. The bipolar cell densities, their cone contacts, their dendritic coverage, and their axonal tiling were measured in retinal whole mounts. The results show that each and all cones are contacted by at least one member of any given type of bipolar cell (not considering genuine blue cones). Consequently, each cone feeds its light signals into a minimum of 10 different bipolar cells. Parallel processing of an image projected onto the retina, therefore, starts at the first synapse of the retina, the cone pedicle. The quantitative analysis suggests that our proposed catalog of 11 cone bipolar cells and one rod bipolar cell is complete, and all major bipolar cell types of the mouse retina appear to have been discovered.
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