| First Author | Coronas V | Year | 2023 |
| Journal | Stem Cells | Volume | 41 |
| Issue | 3 | Pages | 252-259 |
| PubMed ID | 36635952 | Mgi Jnum | J:362230 |
| Mgi Id | MGI:8157900 | Doi | 10.1093/stmcls/sxad003 |
| Citation | Coronas V, et al. (2023) IL-22 Promotes Neural Stem Cell Self-Renewal in the Adult Brain. Stem Cells 41(3):252-259 |
| abstractText | Mainly known for its role in immune defense and inflammation, interleukin 22 (IL-22) has emerged over the past decade as a cytokine involved in the adaptation of stem/progenitor cell activity for tissue homeostasis and repair. IL-22 is present in the brain, which harbors neural stem cells (NSC) in specific niches of which the ventricular-subventricular zone (V-SVZ) is the most important. In this study, we examined a possible effect of IL-22 on NSC in the adult mouse brain. We demonstrate that the IL-22 receptor is expressed in the V-SVZ, mainly in NSC characterized by their SOX2 expression. Addition of IL-22 to V-VSZ cell cultures resulted in an increase in NSC self-renewal, associated with a shift in NSC division mode towards symmetric proliferative divisions at the expense of differentiative divisions. Conversely, loss of IL-22 in knockout mice led to a decrease in neurosphere yield, suggesting a reduction in the NSC population, which was confirmed by the decrease in cells retaining BrdU labeling in IL-22 knockout mice. Our study supports that IL-22 is involved in the development and/or maintenance of V-VSZ NSC and opens new avenues to further investigate the role of IL-22 in NSC biology in health and disease. |
