| First Author | Cox CM | Year | 2024 |
| Journal | PLoS One | Volume | 19 |
| Issue | 5 | Pages | e0296003 |
| PubMed ID | 38787854 | Mgi Jnum | J:351087 |
| Mgi Id | MGI:7644780 | Doi | 10.1371/journal.pone.0296003 |
| Citation | Cox CM, et al. (2024) Regulation of YAP and Wnt signaling by the endosomal protein MAMDC4. PLoS One 19(5):e0296003 |
| abstractText | Maintenance of the intestinal epithelium requires constant self-renewal and regeneration. Tight regulation of proliferation and differentiation of intestinal stem cells within the crypt region is critical to maintaining homeostasis. The transcriptional co-factors beta-catenin and YAP are required for proliferation during normal homeostasis as well as intestinal regeneration after injury: aberrant signaling activity results in over proliferation and tumorigenesis. Although both YAP and beta-catenin activity are controlled along canonical pathways, it is becoming increasingly clear that non-canonical regulation of these transcriptional regulators plays a role in fine tuning their activity. We have shown previously that MAMDC4 (Endotubin, AEGP), an integral membrane protein present in endosomes, regulates both YAP and beta-catenin activity in kidney epithelial cells and in the developing intestinal epithelium. Here we show that MAMDC4 interacts with members of the signalosome and mediates cross-talk between YAP and beta-catenin. Interestingly, this cross-talk occurs through a non-canonical pathway involving interactions between AMOT:YAP and AMOT:beta-catenin. |
