| Primary Identifier | MGI:4941486 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(Phox2b-cre)1Jke |
| Strain of Origin | C57BL/6J | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A cre recombinase cassette was inserted into the ATG translation start codon of the Phox2b gene contained in a BAC clone by recombineering in bacteria. Correctly recombined clones were injected into C57BL/6J pronucei. Multiple lines were produced and crossed to R26R reporter animals to analyze recombination activity. A line selected for further analysis demonstrating recombination activity in the dorsal motor nucleus of the vagus (DMV) in parasympathetic visceral and brachial motor neurons, with low activity/expression in the nucleus of the solitary tract and area postrema. |
