| First Author | Haj-Yasein NN | Year | 2015 |
| Journal | Brain Struct Funct | Volume | 220 |
| Issue | 4 | Pages | 2469-74 |
| PubMed ID | 24744149 | Mgi Jnum | J:323022 |
| Mgi Id | MGI:6839377 | Doi | 10.1007/s00429-014-0767-z |
| Citation | Haj-Yasein NN, et al. (2015) Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus. Brain Struct Funct 220(4):2469-74 |
| abstractText | The coupling between the water channel aquaporin-4 (AQP4) and K(+) transport has attracted much interest. In this study, we assessed the effect of Aqp4 deletion on activity-induced [K(+)]o changes in acute slices from hippocampus and corpus callosum of adult mice. We show that Aqp4 deletion has a layer-specific effect on [K(+)]o that precisely mirrors the known effect on extracellular volume dynamics. In CA1, the peak [K(+)]o in stratum radiatum during 20 Hz stimulation of Schaffer collateral/commissural fibers was significantly higher in Aqp4 (-/-) mice than in wild types, whereas no differences were observed throughout the [K(+)]o recovery phase. In stratum pyramidale and corpus callosum, neither peak [K(+)]o nor post-stimulus [K(+)]o recovery was affected by Aqp4 deletion. Our data suggest that AQP4 modulates [K(+)]o during synaptic stimulation through its effect on extracellular space volume. |
