| First Author | Thrane AS | Year | 2013 |
| Journal | J Cereb Blood Flow Metab | Volume | 33 |
| Issue | 7 | Pages | 996-9 |
| PubMed ID | 23611872 | Mgi Jnum | J:323023 |
| Mgi Id | MGI:6852153 | Doi | 10.1038/jcbfm.2013.63 |
| Citation | Thrane AS, et al. (2013) In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. J Cereb Blood Flow Metab 33(7):996-9 |
| abstractText | Using in vivo two-photon imaging, we show that mice deficient in aquaporin-4 (AQP4) display increased fluorescence of nicotinamide adenine dinucleotide (NADH) when subjected to cortical spreading depression. The increased NADH signal, a proxy of tissue hypoxia, was restricted to microwatershed areas remote from the vasculature. Aqp4 deletion had no effects on the hyperemia response, but slowed [K(+)]o recovery. These observations suggest that K(+) uptake is suppressed in Aqp4(-/-) mice as a consequence of decreased oxygen delivery to tissue located furthest away from the vascular source of oxygen, although increased oxygen consumption may also contribute to our observations. |
