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Publication : Retrosplenial inputs drive visual representations in the medial entorhinal cortex.

First Author  Dubanet O Year  2024
Journal  Cell Rep Volume  43
Issue  7 Pages  114470
PubMed ID  38985682 Mgi Jnum  J:352962
Mgi Id  MGI:7709001 Doi  10.1016/j.celrep.2024.114470
Citation  Dubanet O, et al. (2024) Retrosplenial inputs drive visual representations in the medial entorhinal cortex. Cell Rep 43(7):114470
abstractText  The importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the medial entorhinal cortex (MEC), which receives direct projections from neocortical visual areas, including the retrosplenial cortex (RSC). Here, we perform high-density recordings of MEC neurons in awake, head-fixed mice presented with simple visual stimuli and assess the dynamics of sensory-evoked activity. We find that a large fraction of neurons exhibit robust responses to visual input. Visually responsive cells are located primarily in layer 3 of the dorsal MEC and can be separated into subgroups based on functional and molecular properties. Furthermore, optogenetic suppression of RSC afferents within the MEC strongly reduces visual responses. Overall, our results demonstrate that the MEC can encode simple visual cues in the environment that may contribute to neural representations of location necessary for accurate navigation.
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