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Allele : In(2Itga6-Evx2)44Ddu inversion, Chr 2, Denis Duboule 44
Primary Identifier  MGI:4948261 Allele Type  Targeted
Gene  In(2Itga6-Evx2)44Ddu Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Mice with the Itga6tm1Son allele containing a single loxP site between exons 24 and 26 in cis on chromosome 2 with Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu which also contains a loxP site but in reverse orientation to that in the Itga6 allele were crossed to Hprttm1(cre)Mnn mice. Cre expression resulted in inversion of a segment of chromosome 2 containing exon 26 of Itga6 and extending into the intergenic region between Evx2 and the Hoxd cluster. After the inversion, the Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Dduconstruct and Evx2 were moved to a more centromeric location away from Hoxd.
  • mutations:
  • Inversion
  • synonyms:
  • inv(Nsi-Itgalpha6),
  • HoxD<Inv(TgHd11lacNsi-Itga6)>,
  • inv(Nsi-Itgalpha6),
  • HoxD<Inv(TgHd11lacNsi-Itga6)>
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1 Feature

Trail: Allele

Genome

0 Expresses

67 Mutation Involves

Trail: Allele

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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