Primary Identifier | MGI:4949735 | Allele Type | Targeted |
Gene | Shank3 | Transmission | Germline |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The sequence from exons 4 through 7, which encode the ANK domain, was replaced with a neo cassette. The absence of alpha isoform expression and unchanged beta and gamma isoform expression were confirmed by western blot analysis on brain extracts. |