| First Author | Pang R | Year | 2023 |
| Journal | Behav Brain Res | Volume | 437 |
| Pages | 114149 | PubMed ID | 36206820 |
| Mgi Jnum | J:331678 | Mgi Id | MGI:7366644 |
| Doi | 10.1016/j.bbr.2022.114149 | Citation | Pang R, et al. (2022) Transient hearing abnormalities precede social deficits in a mouse model of autism. Behav Brain Res 437:114149 |
| abstractText | Hearing abnormalities are important symptoms of autism spectrum disorders (ASDs), a neurological and developmental disorder. However, the characteristics of hearing abnormalities associated with ASD during development have not been fully investigated. We found that in Shank3B knockout mice (a high-confidence mouse model of ASD), transient hearing abnormalities can be found in auditory brainstem response, auditory cortical activity, as well as acoustic startle response. More importantly, all hearing abnormalities at 4 weeks were most prominent and preceded the onset of social deficits at 6 weeks. These hearing abnormalities gradually recovered with age. In addition, analysis of ABR data at 4 weeks using Support Vector Machine (SVM) can faithfully predict the genotype of mice with an accuracy of 85.71%. These findings not only revealed hearing changes in Shank3B knockout autistic-like mice during development, but also suggested that hearing abnormalities could potentially be used as an early and effective indicator of ASD risk. |
