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Allele : Tg(PDGFB-LRRK2*G2019S)340Djmo transgene insertion 340, Darren Moore
Primary Identifier  MGI:4950671 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(PDGFB-LRRK2*G2019S)340Djmo
Strain of Origin  (C57BL/6J x C3H/HeJ)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The G2019S-LRRK2 transgene was designed with a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a full length human leucine-rich repeat kinase 2 (LRRK2) cDNA. LRRK2 cDNA was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2*G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease. Line 340 was generated.
  • mutations:
  • Insertion
  • synonyms:
  • G2019S-LRRK2,
  • G2019S-LRRK2
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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