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Allele : Tg(PDGFB-LRRK2*R1441C)574Djmo transgene insertion 574, Darren Moore
Primary Identifier  MGI:4950673 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(PDGFB-LRRK2*R1441C)574Djmo
Strain of Origin  (C57BL/6J x C3H/HeJ)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The R1441C-LRRK2 transgene was designed with a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of full length human leucine-rich repeat kinase 2 (LRRK2) CDNA. LRRK2 cDNA was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2*R1441C mutation associated with autosomal dominant, late-onset Parkinson's disease. Line 574 was generated.
  • mutations:
  • Insertion
  • synonyms:
  • R1441C-LRRK2,
  • R1441C-LRRK2
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

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