| First Author | Van Zandt M | Year | 2019 |
| Journal | Behav Brain Res | Volume | 362 |
| Pages | 7-20 | PubMed ID | 30605713 |
| Mgi Jnum | J:285186 | Mgi Id | MGI:6385597 |
| Doi | 10.1016/j.bbr.2018.12.052 | Citation | Van Zandt M, et al. (2019) Adeno-associated viral overexpression of neuroligin 2 in the mouse hippocampus enhances GABAergic synapses and impairs hippocampal-dependent behaviors. Behav Brain Res 362:7-20 |
| abstractText | The cell adhesion molecule neuroligin2 (NLGN2) regulates GABAergic synapse development, but its role in neural circuit function in the adult hippocampus is unclear. We investigated GABAergic synapses and hippocampus-dependent behaviors following viral-vector-mediated overexpression of NLGN2. Transducing hippocampal neurons with AAV-NLGN2 increased neuronal expression of NLGN2 and membrane localization of GABAergic postsynaptic proteins gephyrin and GABAARgamma2, and presynaptic vesicular GABA transporter protein (VGAT) suggesting trans-synaptic enhancement of GABAergic synapses. In contrast, glutamatergic postsynaptic density protein-95 (PSD-95) and presynaptic vesicular glutamate transporter (VGLUT) protein were unaltered. Moreover, AAV-NLGN2 significantly increased parvalbumin immunoreactive (PV(+)) synaptic boutons co-localized with postsynaptic gephyrin(+) puncta. Furthermore, these changes were demonstrated to lead to cognitive impairments as shown in a battery of hippocampal-dependent mnemonic tasks and social behaviors. |
