| Primary Identifier | MGI:4971042 | Allele Type | Gene trapped |
| Attribute String | Modified isoform(s) | Gene | Sgce |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | This allele is maternally imprinted. This gene trap is no longer available through the Toronto Centre for Phenogenomics. |
| molecularNote | The terminal exons (3' to exon 9) of Sgce were disrupted by the gene trap vector insertion. Homozygotes and heterozygotes with the paternally inherited allele show 60-70% reductions in expression of total Sgce. IAP-mass spectrometry and qRT-PCR shows that the major and brain-specific isoforms are eliminated while short isoforms terminating 5' to intron 9 and small amounts of a chimeric epsilon-sarcoglycan/beta-gal fusion protein are preserved. |
