| First Author | Studer M | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5179 | Pages | 1728-32 |
| PubMed ID | 7916164 | Mgi Jnum | J:20433 |
| Mgi Id | MGI:68522 | Doi | 10.1126/science.7916164 |
| Citation | Studer M, et al. (1994) Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science 265(5179):1728-32 |
| abstractText | After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point mutations in which allow expression to spread into adjacent rhombomeres. Retinoids and their nuclear receptors may therefore participate in sharpening segment-restricted expression of Hoxb-1 during rhombomere boundary formation. |
