| First Author | Apostolides PF | Year | 2016 |
| Journal | Neuron | Volume | 89 |
| Issue | 4 | Pages | 770-83 |
| PubMed ID | 26833135 | Mgi Jnum | J:253261 |
| Mgi Id | MGI:6109402 | Doi | 10.1016/j.neuron.2015.12.040 |
| Citation | Apostolides PF, et al. (2016) Axonal Filtering Allows Reliable Output during Dendritic Plateau-Driven Complex Spiking in CA1 Neurons. Neuron 89(4):770-83 |
| abstractText | In CA1 pyramidal neurons, correlated inputs trigger dendritic plateau potentials that drive neuronal plasticity and firing rate modulation. Given the strong electrotonic coupling between soma and axon, the >25 mV depolarization associated with the plateau could propagate through the axon to influence action potential initiation, propagation, and neurotransmitter release. We examined this issue in brain slices, awake mice, and a computational model. Despite profoundly inactivating somatic and proximal axon Na(+) channels, plateaus evoked action potentials that recovered to full amplitude in the distal axon (>150 mum) and triggered neurotransmitter release similar to regular spiking. This effect was due to strong attenuation of plateau depolarizations by axonal K(+) channels, allowing full axon repolarization and Na(+) channel deinactivation. High-pass filtering of dendritic plateaus by axonal K(+) channels should thus enable accurate transmission of gain-modulated firing rates, allowing neuronal firing to be efficiently read out by downstream regions as a simple rate code. |
