| First Author | Williams SR | Year | 2019 |
| Journal | Neuron | Volume | 101 |
| Issue | 3 | Pages | 486-499.e4 |
| PubMed ID | 30594427 | Mgi Jnum | J:272056 |
| Mgi Id | MGI:6282680 | Doi | 10.1016/j.neuron.2018.11.035 |
| Citation | Williams SR, et al. (2019) A Dendritic Substrate for the Cholinergic Control of Neocortical Output Neurons. Neuron 101(3):486-499.e4 |
| abstractText | The ascending cholinergic system dynamically regulates sensory perception and cognitive function, but it remains unclear how this modulation is executed in neocortical circuits. Here, we demonstrate that the cholinergic system controls the integrative operations of neocortical principal neurons by modulating dendritic excitability. Direct dendritic recordings revealed that the optogenetic-evoked release of acetylcholine (ACh) transformed the pattern of dendritic integration in layer 5B pyramidal neurons, leading to the generation of dendritic plateau potentials which powerfully drove repetitive action potential output. In contrast, the synaptic release of ACh did not positively modulate axo-somatic excitability. Mechanistically, the transformation of dendritic integration was mediated by the muscarinic ACh receptor-dependent enhancement of dendritic R-type calcium channel activity, a compartment-dependent modulation which decisively controlled the associative computations executed by layer 5B pyramidal neurons. Our findings therefore reveal a biophysical mechanism by which the cholinergic system controls dendritic computations causally linked to perceptual detection. |
