| First Author | Williams SR | Year | 2023 |
| Journal | Neuron | PubMed ID | 37086722 |
| Mgi Jnum | J:335862 | Mgi Id | MGI:7485686 |
| Doi | 10.1016/j.neuron.2023.03.038 | Citation | Williams SR, et al. (2023) Compartment-specific dendritic information processing in striatal cholinergic interneurons is reconfigured by peptide neuromodulation. Neuron |
| abstractText | Cholinergic interneurons are central hubs of the striatal neuronal network, controlling information processing in a behavioral-state-dependent manner. It remains unknown, however, how such state transitions influence the integrative properties of these neurons. To address this, we made simultaneous somato-dendritic recordings from identified rodent cholinergic interneurons, revealing that action potentials are initiated at dendritic sites because of a dendritic axonal origin. Functionally, this anatomical arrangement ensured that the action potential initiation threshold was lowest at axon-bearing dendritic sites, a privilege efficacy powerfully accentuated at the hyperpolarized membrane potentials achieved in cholinergic interneurons following salient behavioral stimuli. Experimental analysis revealed the voltage-dependent attenuation of the efficacy of non-axon-bearing dendritic excitatory input was mediated by the recruitment of dendritic potassium channels, a regulatory mechanism that, in turn, was controlled by the pharmacological activation of neurokinin receptors. Together, these results indicate that the neuropeptide microenvironment dynamically controls state- and compartment-dependent dendritic information processing in striatal cholinergic interneurons. |
