Primary Identifier | MGI:5049943 | Allele Type | Targeted |
Attribute String | Modified regulatory region, Null/knockout | Gene | Rr14 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Homologous recombination replaced a segment of genomic DNA located between Hbb-bh0 and Hbb-bh1 with a loxP site flanked neomycin resistance gene cassette. The segment of DNA replaced extended from 7500 bp downstream of the epsilon y-globin transcription start site to 8231 bp downstream (731 bp). The selectable marker was subsequently removed by crossing to Tg(CMV-cre)1Cgn transgenic mice. |