| Primary Identifier | MGI:5052111 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Mapt-MAPT*)#Hanr |
| Strain of Origin | C57BL/6 x BALB/c | Is Recombinase | false |
| Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: tauopathy (J:137947) |
| molecularNote | A fragment of the rat Mapt promoter drives expression of a human MAPT cDNA coding for the short four repeat isoform, containing 2 pathogenic mutations, K257T and P301S. Expression of the mutant MAPT protein is about 5-10% that of the endogenous protein. |
