| First Author | Mangan MS | Year | 2017 |
| Journal | Mol Immunol | Volume | 82 |
| Pages | 50-56 | PubMed ID | 28024184 |
| Mgi Jnum | J:274511 | Mgi Id | MGI:6295275 |
| Doi | 10.1016/j.molimm.2016.12.011 | Citation | Mangan MS, et al. (2017) Serpinb9 is a marker of antigen cross-presenting dendritic cells. Mol Immunol 82:50-56 |
| abstractText | Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated. Recently, we have demonstrated that Sb9 plays a grB-independent role in cross-presentation of antigens by CD8(+) DCs. Here, using a mouse line expressing green fluorescent protein knocked in under the control of the Sb9 promoter, we demonstrate that Sb9 expression is highest in those tissue-resident and migratory DC subsets capable of cross-presentation. Further, we show that CD8(+) DCs can be divided into two subsets based on Sb9 expression, and that only the subset expressing higher levels of Sb9 is capable of cross-presentation. These findings add support for role for Sb9 cross-presentation, and indicate that high Sb9 expression is a novel marker of cross-presentation capable DCs. |
