| First Author | Contreras-López R | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 1 | Pages | 112000 |
| PubMed ID | 36656714 | Mgi Jnum | J:333444 |
| Mgi Id | MGI:7434065 | Doi | 10.1016/j.celrep.2023.112000 |
| Citation | Contreras-Lopez R, et al. (2023) The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement. Cell Rep 42(1):112000 |
| abstractText | Cerebellar-thalamo-striatal synaptic communication has been implicated in a wide range of behaviors, including goal-directed actions, and is altered in cerebellar dystonia. However, its detailed connectivity through the thalamus and its contribution to the execution of forelimb movements is unclear. Here, we use trans-synaptic and retrograde tracing, ex vivo slice recordings, and optogenetic inhibitions during the execution of unidirectional or sequential joystick displacements to demonstrate that the deep cerebellar nuclei (DCN) influence the dorsal striatum with a very high probability. We show that this mainly occurs through the centrolateral (CL), parafascicular (PF), and ventrolateral (VL) nuclei of the thalamus, observing that the DCN-->VL and DCN-->CL pathways contribute to the execution of unidirectional forelimb displacements while the DCN-->PF and DCN-->thalamo-->striatal pathways contribute to the appropriate execution of forelimb reaching and sequential displacements. These findings highlight specific contributions of the different cerebellar-thalamo-striatal paths to the control of skilled forelimb movement. |
