| First Author | Ryoo J | Year | 2021 |
| Journal | Front Neurosci | Volume | 15 |
| Pages | 716147 | PubMed ID | 34497488 |
| Mgi Jnum | J:312877 | Mgi Id | MGI:6793341 |
| Doi | 10.3389/fnins.2021.716147 | Citation | Ryoo J, et al. (2021) An Inhibitory Medial Preoptic Circuit Mediates Innate Exploration. Front Neurosci 15:716147 |
| abstractText | Animals have an innate motivation to explore objects and environments with unknown values. To this end, they need to activate neural pathways that enable exploration. Here, we reveal that photostimulation of a subset of medial preoptic area (MPA) neurons expressing the vesicular-GABA transporter gene (vgat+) and sending axonal projections to the ventrolateral periaqueductal gray (vPAG) increases exploration in a chamber but causes no place preference when tested there without photostimulation. Photoinhibition of MPA(vgat)-vPAG projections leads to no emotional changes as measured by normal activity in an open field assay. Electrophysiological recordings revealed that most GABAergic vPAG neurons are inhibited by MPA(vgat) neurons. In contrast to a previous report that suggested that MPA(vgat)-vPAG neurons may impart positive valence to induce place preference, our results suggest that these neurons can increase innate exploration. |
