| First Author | Nakamura NH | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 4391 |
| PubMed ID | 37500646 | Mgi Jnum | J:338560 |
| Mgi Id | MGI:7513393 | Doi | 10.1038/s41467-023-40139-7 |
| Citation | Nakamura NH, et al. (2023) Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding. Nat Commun 14(1):4391 |
| abstractText | During offline brain states, such as sleep and memory consolidation, respiration coordinates hippocampal activity. However, the role of breathing during online memory traces remains unclear. Here, we show that respiration can be recruited during online memory encoding. Optogenetic manipulation was used to control activation of the primary inspiratory rhythm generator PreBotzinger complex (PreBotC) in transgenic mice. When intermittent PreBotC-induced apnea covered the object exploration time during encoding, novel object detection was impaired. Moreover, the mice did not exhibit freezing behavior during presentation of fear-conditioned stimuli (CS(+)) when PreBotC-induced apnea occurred at the exact time of encoding. This apnea did not evoke changes in CA3 cell ensembles between presentations of CS(+) and conditioned inhibition (CS(-)), whereas in normal breathing, CS(+) presentations produced dynamic changes. Our findings demonstrate that components of central respiratory activity (e.g., frequency) during online encoding strongly contribute to shaping hippocampal ensemble dynamics and memory performance. |
