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Allele : Etv6<tm1.1(RUNX1,hsb5)Lvdw> ets variant 6; targeted mutation 1.1, Louise van der Weyden
Primary Identifier  MGI:5284820 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence, Null/knockout Gene  Etv6
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A construct, which contains a lox66, exons 1 through 6 of human RUNX1 (hAML1), IRES, hyperactive variant of sleeping beauty (hsb5), polyadenylation sequence, FRT-flanked puro cassette, and lox71 site, was inserted into intron 5. Mice express a Etv6/RUNX1 fusion to replicate the TEL-AML1 translocation associated with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and hsb5. Flp-mediated recombination removed the puro cassette. Embryonic lethality indicates that no functional endogenous protein is produced despite the production of the endogenous transcript.
  • mutations:
  • Insertion
  • synonyms:
  • Etv6<RUNX1>,
  • Etv6<RUNX1>
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

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