| First Author | Song L | Year | 2011 |
| Journal | J Lipid Res | Volume | 52 |
| Issue | 8 | Pages | 1542-50 |
| PubMed ID | 21572087 | Mgi Jnum | J:175275 |
| Mgi Id | MGI:5285055 | Doi | 10.1194/jlr.M015412 |
| Citation | Song L, et al. (2011) Deletion of the murine scavenger receptor CD68. J Lipid Res 52(8):1542-50 |
| abstractText | Scavenger receptors (ScRs) are a structurally unrelated family of receptors with the ability to bind modified low density lipoprotein (LDL) as well as a broad range of polyanionic ligands. CD68, whose expression is restricted to mononuclear phagocytes, is a unique ScR family member, owing to its lysosome associated membrane protein (LAMP)-like domain and predominant endosomal distribution. Knockout (ko) mice were generated to directly evaluate the role murine CD68 may play in oxidized LDL (Ox-LDL) uptake. However, CD68/ macrophages took up Ox-LDL robustly. Likewise, no defects were observed in the ability of CD68/ mononuclear phagocytes to take up or mount an effective innate response against a number of microbes. Curiously, CD68/ mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4 T-cells, raising the possibility that CD68 may function either to negatively regulate antigen uptake, loading, or major histocompatibility complex class II (MHC-II) trafficking. |
