| Primary Identifier | MGI:5286106 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence, Reporter | Gene | Tg(CMV-KRAS*G12V,-EGFP)#Mjar |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A CMV promoter drives ubiquitous expression of a human KRAS minigene with a nucleotide substitution that results in the amino acid substitution of valine for glycine at position 12, an IRES, and EGFP. The minigene is preceded by a floxed neo cassette. Cre-mediated recombination is required to allow for expression of the Kras mutation that occurs in 40-50% of human colorectal adenomas and carcinomas. |
