| First Author | Sebrié C | Year | 2008 |
| Journal | Anat Rec (Hoboken) | Volume | 291 |
| Issue | 3 | Pages | 254-62 |
| PubMed ID | 18231969 | Mgi Jnum | J:289033 |
| Mgi Id | MGI:6435861 | Doi | 10.1002/ar.20640 |
| Citation | Sebrie C, et al. (2008) Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21. Anat Rec (Hoboken) 291(3):254-62 |
| abstractText | A yeast artificial chromosome (YAC) transgenic murine model of partial trisomy 21 overexpressing five human genes -- including DYRK1A, which encodes a serine threonine kinase involved in cell cycle control -- has been shown to present an increase in brain weight. We analyzed this new phenotype by measuring total and regional brain volumes at different ages, using a 7 Tesla magnetic resonance imaging volumetric approach. Volumetric measurements showed a total volume increase of 13.6% in adult mice. Changes in brain morphogenesis were already visible at a very early postnatal stage (postnatal days 2-7). Region-specific changes were characterized from postnatal day 15 to 5 months. These results, made it possible to define region-specific effects of DYRK1A overexpression, with the strongest increase seen in the thalamus-hypothalamus area (24%). |
