| First Author | Jiao P | Year | 2012 |
| Journal | Endocrinology | Volume | 153 |
| Issue | 1 | Pages | 154-65 |
| PubMed ID | 22067324 | Mgi Jnum | J:181649 |
| Mgi Id | MGI:5312185 | Doi | 10.1210/en.2011-1346 |
| Citation | Jiao P, et al. (2012) Constitutive activation of IKKbeta in adipose tissue prevents diet-induced obesity in mice. Endocrinology 153(1):154-65 |
| abstractText | The IkappaB kinase beta (IKKbeta) is a master kinase involved in obesity-related inflammation and insulin resistance through nuclear factor kappaB dependent and independent pathways. However, the effect of IKKbeta activation in adipose tissue, the organ critical for storage of excessive energy and initiation of inflammatory responses in the context of obesity, on systemic insulin sensitivity and metabolism, has not been investigated. In our study, we found that mice overexpressing the constitutively active IKKbeta in adipose tissue under the control of murine adipocyte fatty acid binding protein (aP2) promoter were protected from age-related and diet-induced body weight gains, despite increased food intake. The aP2-IKKbeta SE mice have significantly reduced weights in all white adipose tissue depots and reduced triglyceride contents in adipose tissue, liver, and muscle. Despite increased systemic and tissue inflammation, aP2-IKKbeta SE mice displayed decreased blood glucose levels, improved glucose, and insulin tolerance. This may be at least partially attributable to increased energy expenditure. Histological analysis revealed presence of many small adipocytes in white adipose tissue of aP2-IKKbeta SE mice fed on high-fat diet. Furthermore, transgenic expression of IKKbeta in adipose tissue improved high-fat diet-induced hepatosteatosis. Collectively, increased energy expenditure and reduced plasma free fatty acid levels may contribute to enhanced systemic insulin sensitivity in aP2-IKKbeta SE mice. Our study demonstrates that presence of inflammation in adipose tissue before the development of obesity has beneficial effect on metabolism. |
