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Allele : Sox2<tm3(TK)Hoch> SRY (sex determining region Y)-box 2; targeted mutation 2, Konrad Hochedlinger
Primary Identifier  MGI:5296002 Allele Type  Targeted
Attribute String  Inserted expressed sequence Gene  Sox2
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A puromycin-deltaTK (truncated thymidine kinase) sequence was inserted into the Sox2 locus by homologous recombination in V6.5 ES cells, placing TK under control of endogenous regulatory elements. In the mouse line generated, exposure to gancyclovir (GCV) will result in death of Sox2-positive (TK-expressing) dividing cells.
  • mutations:
  • Insertion
  • synonyms:
  • Sox2<TK>,
  • Sox2<TK>
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Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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