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Allele : Tg(tetO-APPSwInd)Dbo transgene insertion, David R Borchelt
Primary Identifier  MGI:5295154 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(tetO-APPSwInd)Dbo
Strain of Origin  (C57BL/6J x C3H/HeJ)F1 Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2. Lines 18, 102, 107, and 885 were established. When mice are crossed with a line expressing a tTA transgene, these mice show the greatest doxycycline sensitivity for transgene suppression. The pound symbol (#) is used when no line is specified and/or lines are pooled.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(tetO-APP*Swe*Ind)#Dbo,
  • TetO-hAPP,
  • TetO-hAPP,
  • Tg(tetO-APP*Swe*Ind)#Dbo
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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10 Publication categories

Trail: Allele




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