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Allele : Tg(Vsx2-cre)2690Chow transgene insertion 2690, Robert L Chow
Primary Identifier  MGI:5297524 Allele Type  Transgenic
Attribute String  Recombinase Gene  Tg(Vsx2-cre)2690Chow
Strain of Origin  C57BL/6 x C3H Is Recombinase  true
Is Wild Type  false
molecularNote  Cre recombinase cDNA was cloned downstream of a 5.3kb upstream region of the Vsx2 gene. A 1.9 kb region containing a 164 bp bipolar enhancer was cloned 5' of the 5.3 kb region. An SV40 polyadenylation sequence was inserted downstream of cre. The 1.9 kb region has been identified as a putative retinal enhancer (PRE) and lies within a conserved non-coding region that is within the breakpoint of the Vsx2 (ocular retardation 2J) mutation. 6 founder lines carried the transgene, with 4 (2690, 2695, 2700, and 2717) exhibiting cre expression detected by immunolabeling.
  • mutations:
  • Insertion
  • synonyms:
  • Vsx2-5.3-PRE-Cre,
  • Vsx2-5.3-PRE-Cre
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0 Mutation Involves

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Mouse alleles --> Mammalian phenotypes (MP terms)

 

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