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Allele : Del(17D17Jcs41-D17Jcs15)8Jcs deletion, Chr 17, John C Schimenti 8
Primary Identifier  MGI:5303075 Allele Type  Radiation induced
Attribute String  Null/knockout Gene  Del(17D17Jcs41-D17Jcs15)8Jcs
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A beta-Actin-Neo and HSC-tk sequence was inserted into the BglII site in the last exon of the Nkx2-5 gene in v6.5 ES cells. A population of properly targeted ES cells was exposed to 4Gy of radiation from a Cesium- 137 source. Deletion mutants were selected in ES cells by restoration of "tk" sensitivity. Four mouse stocks and 11 mutated ES cell lines were established.
  • mutations:
  • Intragenic deletion,
  • Intergenic deletion
  • synonyms:
  • D17Nkx2.5<df5J>,
  • D17Nkx2.5<df5J>
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1 Feature

Trail: Allele

Genome

0 Expresses

113 Mutation Involves

Trail: Allele

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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