| Primary Identifier | MGI:5307058 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(CTSG-NUMA1/RARA)#Skr |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene consists of a fusion protein containing the N-terminal globular head domain and long central coiled-coil motif of NUMA1, including the oligomerization domain, and the C-terminus, domains C-F, of RARA, including the ATRA-binding site, RA-dependent DNA-binding site, and retinoid X receptor alpha and nuclear corepressor/coactivator interfaces, under the control of the human cathepsin G promoter. This fusion protein results from a translocation t(11:17)(q13;q21) associated with human cases of acute promyelocytic leukemia. The CTSG promoter drives expression in immature cells of the neutrophil lineage. RT-PCR indicates transgene expression in multiple organs at 4.5 months of age. Two lines were made but no line numbers were specified. |
